Aug. 18, 2026
Chemicals
Pyridine-4-boronic acid, identified by CAS 1692-15-5, is a heteroaryl boronic acid mainly used as a building block in organic synthesis. Its most important application is palladium-catalyzed Suzuki–Miyaura coupling, where the boronic acid group can react with suitable aryl or heteroaryl halides to form carbon–carbon bonds. I supply this intermediate to research, pharmaceutical, agrochemical, and specialty chemical customers who need a functionalized pyridine fragment for further synthesis rather than a finished drug or formulated product.
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The compound combines two useful features: a pyridine nitrogen that can influence polarity, coordination, and molecular recognition, and a boronic acid group that provides a practical coupling handle. Its molecular formula is commonly represented as C5H6BNO2, with a calculated molecular weight of approximately 122.92 g/mol. The correct purchasing decision depends on the intended reaction, required quality attributes, packaging, documentation, and scale.
The primary function of Pyridine-4-boronic Acid is to introduce a pyridin-4-yl group into a target molecule. In a typical Suzuki–Miyaura reaction, the boronic acid reacts with an aryl, heteroaryl, or vinyl halide in the presence of a suitable catalyst and base. This transformation is widely used because it can connect two complex fragments at a defined position, supporting efficient route development in medicinal and process chemistry.
Reaction performance is not determined by the boronic acid alone. The choice of catalyst, ligand, base, solvent, temperature, water content, and reaction time can affect conversion and selectivity. For this reason, I recommend evaluating the material together with the customer’s complete reaction system rather than treating a catalog specification as a guarantee of performance in every process.
The pyridine ring is a common heteroaromatic motif in biologically active molecules and functional organic compounds. Its ring nitrogen can act as a hydrogen-bond acceptor and can alter the electronic and physicochemical properties of a molecule. By using Pyridine-4-boronic Acid as a coupling partner, chemists can attach this ring to another aromatic or heteroaromatic fragment during a later stage of synthesis.
This makes the compound useful for building molecular libraries and analog series. Researchers can vary the second coupling partner while retaining the same pyridine-containing fragment, helping them investigate structure–activity relationships. Any biological activity, toxicity profile, or final product performance must be established for the completed molecule through appropriate testing; it should not be inferred from the intermediate itself.
Pharmaceutical researchers may use Pyridine-4-boronic Acid to prepare small molecules containing a 4-substituted pyridine unit. It can support discovery-stage synthesis, analog generation, route scouting, and process development when a carbon–carbon bond must be formed between a pyridine ring and another organic fragment. The material is therefore best viewed as a research and manufacturing intermediate, not as an active pharmaceutical ingredient.
In a discovery program, the compound may be selected when the target structure requires a pyridine ring at a specific connectivity. A buyer may also compare it with a corresponding pyridyl halide, trifluoroborate, or protected boronic ester. The preferred option depends on reagent stability, reaction conditions, downstream purification, and the scale of the intended work.
Heteroaryl building blocks are also relevant to the preparation of crop-protection research compounds and related specialty intermediates. Pyridine-4-boronic Acid can be considered when a synthesis requires a pyridinyl fragment and a cross-coupling step offers a practical route to the desired structure. However, its suitability must be confirmed against the specific synthetic route, regulatory requirements, impurity profile, and final-product specification.
Beyond pharmaceutical and agrochemical research, pyridine-containing intermediates can be used in the development of ligands, coordination compounds, molecular probes, and other specialty organic materials. The pyridine nitrogen may provide a coordination site, while the former boronic acid position allows connection to another aromatic unit. These applications are project-specific, so customers normally need technical consultation before selecting a material for scale-up.
Buyers may encounter Pyridine-4-boronic Acid as a neat solid or as a material supplied under a defined packaging and handling specification. The free boronic acid is attractive when the customer wants to use the acid functionality directly in a coupling reaction. In other projects, chemists may prefer a more stable derivative, such as a cyclic boronic ester, depending on storage, transport, reaction compatibility, and the need for hydrolysis before use.
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These formats should not be treated as automatically interchangeable. A boronic ester may show different solubility and weighing characteristics, while a free boronic acid may be selected for direct reaction screening. When requesting a quotation, I ask customers to identify the exact chemical form, CAS number, target quantity, purity requirement, and intended application so that the proposed material matches the actual process.
The identity of the material should be confirmed by its name, CAS number, molecular formula, and molecular weight. For Pyridine-4-boronic Acid, CAS 1692-15-5 and an approximate molecular weight of 122.92 g/mol are useful reference points for procurement and laboratory calculations. Buyers should also review appearance, assay or purity method, water content where relevant, residual solvents, inorganic residues, and the availability of analytical documentation.
Documentation may include a certificate of analysis, safety data sheet, batch or lot identification, and analytical data agreed during the quotation process. Depending on the application, customers may request chromatographic purity, nuclear magnetic resonance data, mass spectrometry confirmation, or additional impurity information. I do not recommend assuming that a standard specification is adequate for a regulated or scale-sensitive process without checking the customer’s internal quality requirements.
| Procurement item | Why it matters |
|---|---|
| CAS 1692-15-5 and chemical form | Confirms that the quoted material matches the intended intermediate. |
| Purity and analytical method | Helps the buyer assess suitability for screening, route development, or production. |
| Packaging and quantity | Influences handling, shipping, storage, and total procurement cost. |
| CoA, SDS, and lot information | Supports internal approval, traceability, and safe laboratory handling. |
Start with the planned reaction and determine whether the process requires a free boronic acid or a related derivative. Consider the coupling partner, catalyst system, solvent, base, purification method, and expected scale. A material that is suitable for a small-scale research screen may not automatically meet the impurity, reproducibility, or documentation expectations of a manufacturing route.
Quantity should be based on the number of experiments, expected yield, resynthesis needs, and process-development schedule. Buyers should request the available pack size, current stock position, production lead time, shipping conditions, and shelf-life or retest information when applicable. I can evaluate the inquiry more accurately when the customer provides a target quantity such as 100 g, 1 kg, or another defined requirement, rather than requesting a general price only.
A capable supplier should be able to clarify chemical identity, documentation, packaging, and commercial terms before an order is placed. For projects involving scale-up, communication about batch consistency, change notification, and repeat supply is also important. These factors reduce avoidable procurement risk, although final qualification remains the buyer’s responsibility.
At Maison Chemical, I support customers sourcing Pyridine-4-boronic Acid for laboratory research, intermediate development, and commercial chemical programs. I can help organize inquiries around CAS 1692-15-5, required quantity, target purity, packaging preference, destination, and documentation needs. This information allows me to distinguish a routine sample request from a project requiring a larger-volume supply assessment.
I also provide practical communication on available specifications, quotation conditions, lead-time expectations, and relevant quality documents. Where the application is sensitive to impurities or format, I encourage customers to share the intended reaction or internal specification before confirming the purchase. I avoid presenting unverified performance claims, because reaction success depends on the complete process and must be validated by the user.
Pyridine-4-boronic Acid is most suitable when your synthesis requires a pyridin-4-yl fragment and a boronic-acid-based coupling strategy fits your route. It is particularly relevant to medicinal chemistry, pharmaceutical intermediate development, agrochemical research, and specialty organic synthesis. Its value lies in providing a defined heteroaryl building block, but the final suitability depends on reaction conditions, material quality, and project-specific requirements.
As a next step, prepare your target quantity, desired purity, chemical form, delivery destination, and documentation requirements. Send these details to Maison Chemical for a focused supply review and quotation. I can then help you assess the appropriate specification and commercial route for Pyridine-4-boronic Acid CAS 1692-15-5.
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