Oct. 13, 2026
Chemicals
Pyridine-4-boronic acid, also called 4-pyridylboronic acid, is a heteroaryl boronic acid used as a building block in organic synthesis. Its defining structural feature is a boronic acid group attached at the 4-position of a pyridine ring, making it useful in palladium-catalyzed carbon–carbon bond-forming reactions, especially Suzuki–Miyaura coupling. The compound is identified by CAS 1692-15-5 and has the molecular formula C5H6BNO2 and a molecular weight of approximately 122.92 g/mol. Below, we explain its chemistry, common applications, specification checks, and the information buyers should confirm before placing an order.
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Pyridine-4-boronic acid is an organoboron compound derived from pyridine. In its structure, a boronic acid group, written as –B(OH)2, is attached to the carbon opposite the nitrogen atom in the pyridine ring. The nitrogen-containing ring makes this compound a heteroaryl boronic acid, distinguishing it from phenylboronic acid and other carbocyclic aryl boronic acids.
In synthesis, the boronic acid group can participate in cross-coupling reactions with suitable organic halides or related coupling partners. Under compatible conditions, the reaction forms a new carbon–carbon bond and incorporates the pyridin-4-yl fragment into a target molecule. The pyridine nitrogen remains part of the product and can affect its polarity, basicity, and interactions with other components.
The most common synthetic role of pyridine-4-boronic acid is as a coupling partner in Suzuki–Miyaura chemistry. It may be used to introduce a pyridin-4-yl substituent onto an aromatic or vinyl framework when the other coupling partner and reaction conditions are suitable. Chemists select it when the desired product requires a pyridine ring connected through its 4-position.
Reaction conditions are substrate-dependent. Catalyst choice, base, solvent, temperature, and reaction time can influence conversion and selectivity, while heteroaromatic nitrogen may interact with some catalyst systems. Researchers should assess compatibility in their own reaction design rather than assume that one protocol will work for every substrate.
The compound can serve as a building block during the preparation of more complex molecules. For example, a pyridyl group may be incorporated into candidate structures for medicinal chemistry, materials research, or other laboratory-scale synthesis programs. These are areas of potential use, not claims that the reagent itself has a particular biological, commercial, or performance outcome.
Its value is therefore tied to the target structure and route design. A synthetic team may compare it with alternative pyridyl coupling partners based on reactivity, availability, compatibility with functional groups, and the required substitution pattern. Route selection should also consider downstream purification and the stability of the intermediates being prepared.
The identifiers below help buyers and technical teams confirm that they are discussing the intended compound. The data listed here describe the chemical identity; they should not be treated as a batch-specific certificate of analysis. For commercial purchasing, we recommend confirming the exact product form and current release specifications with the supplier.
| Property | Information | Buyer note |
|---|---|---|
| Product name | Pyridine-4-boronic acid | Also referred to as 4-pyridylboronic acid |
| CAS number | 1692-15-5 | Use the CAS number alongside the name when requesting a quotation |
| Molecular formula | C5H6BNO2 | Confirm whether the offered material is anhydrous or supplied in another form |
| Molecular weight | Approximately 122.92 g/mol | Useful for stoichiometric calculations and identity checks |
| Functional group | Aryl boronic acid | Relevant to coupling chemistry and storage considerations |
Commercial specifications may define assay or purity, identification tests, appearance, water content, and other quality attributes. The appropriate limits depend on the buyer’s application and the supplier’s validated product specification. As a purchasing example—not a statement of Maison Chemical’s standard grade—a buyer might request a minimum assay of 97% or 98% when that threshold suits the project.
Water content and hydrate status deserve particular attention for boronic acids because the stated formula and molecular weight may differ from those of a hydrated or otherwise specified form. Ask for the product’s exact designation and review the accompanying certificate of analysis for the delivered batch. If a particular analytical method or impurity limit is required, state it before quotation so that feasibility can be confirmed.
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For medicinal chemistry research, the reagent may be considered when a molecule design calls for a pyridine ring attached through the 4-position. For discovery or process-development work, it can provide a route to pyridyl-substituted intermediates, subject to experimental evaluation. In materials-related synthesis, it may be relevant when the target structure incorporates a pyridine unit, but suitability depends on the intended material and synthetic route.
In each case, the key question is not simply whether the compound is available, but whether it meets the reaction and quality requirements of the project. A chemist should check the coupling partner, functional-group tolerance, catalyst compatibility, and work-up needs. A small-scale feasibility experiment can help determine whether the selected reagent and conditions are appropriate before a route is scaled.
Start by defining the intended application, required quantity, and acceptance criteria. A research screen may prioritize availability and fit-for-purpose identity documentation, while a process-development program may need tighter impurity controls, defined analytical methods, or additional traceability. Do not assume that a higher stated assay alone resolves every quality requirement.
Boronic acids can show condition-dependent behavior, and some coupling systems may be affected by protodeboronation or other loss of the boron-containing group. The extent of these effects depends on the molecule and reaction environment, so we avoid treating them as universal outcomes. Review current handling guidance and the product documentation, and select storage and reaction conditions in line with the supplier’s recommendations and your laboratory procedures.
Also distinguish the material specification from the process result. A conforming reagent is one input to a reaction, but substrate quality, catalyst activity, equipment, and execution can all affect conversion and isolated yield. If a process has narrow operating limits, discuss the relevant technical requirements with your supplier before purchasing.
At Maison Chemical, we support B2B inquiries for Pyridine-4-boronic acid CAS 1692-15-5 by helping buyers clarify product identity, quantity, specification needs, and documentation expectations. Availability, packaging, lead time, and any requested quality attributes should be confirmed for the specific order rather than assumed from a general product description. This approach helps align the requested material with the buyer’s purchasing and project requirements.
When requesting a quotation, include your required quantity, destination, target assay or other specification limits, and any document requirements. If you have a preferred analytical method or need confirmation of the product form, state that clearly. We can then review the request and confirm what can be offered for the requested shipment.
Pyridine-4-boronic acid (CAS 1692-15-5) is a heteroaryl boronic acid used primarily as a pyridin-4-yl building block in suitable cross-coupling chemistry. Its key identity data are the formula C5H6BNO2 and molecular weight of approximately 122.92 g/mol, while actual purchasing specifications must be confirmed for the offered batch. It may be relevant when your target structure requires a pyridine ring connected at the 4-position, but reaction suitability should be assessed for the specific substrate and conditions.
For your next step, define the required quantity, assay, product form, and documentation, then request batch-specific information and a quotation from Maison Chemical. Share any application-specific limits before order confirmation so that the requested supply can be evaluated against your project needs. This gives your team a clear basis for comparing the material and planning its use.
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