2,4-Difluorophenylboronic Acid CAS 144025-03-6: Properties, Uses, and Handling Guide

I identify 2,4-difluorophenylboronic acid as an aryl boronic acid building block with the CAS number 144025-03-6. Its structure contains a phenyl ring bearing fluorine substituents at the 2- and 4-positions and one boronic acid functional group. I generally evaluate this material as a research intermediate or synthetic reagent, not as a finished active pharmaceutical ingredient. Before purchase or use, I recommend confirming the current supplier specification, certificate of analysis (CoA), safety data sheet (SDS), molecular descriptors, packaging, and shipment requirements.

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1. Chemical Identity and Basic Information

2,4-Difluorophenylboronic acid belongs to the organic boronic acid category. The “2,4-difluorophenyl” description indicates two fluorine atoms attached to the aromatic ring at positions 2 and 4 relative to the boronic acid-substituted carbon. This positional pattern is important because it distinguishes the compound from other difluorophenylboronic acid isomers, which may have different identifiers and reactivity profiles.

The compound contains one boronic acid group, commonly represented as a carbon–boron functionality with two oxygen atoms in the boronic acid moiety. Reference databases list the molecular formula as C₆H₅BF₂O₂ and the molecular weight as approximately 157.91 g/mol; I treat these values as identity-reference data rather than a substitute for product-specific documentation. PubChem is a useful authoritative starting point for cross-checking chemical identity, structure, and calculated properties, but the supplier’s current documentation should control purchasing decisions.

When I compare a quotation, catalog page, or sample label, I check the compound name, CAS number, structure, formula, molecular weight, and any available SMILES or InChI data. I also confirm that the requested material is not a protected boronate ester or a different difluorophenyl isomer. A mismatch in even one identity field should be resolved before the material enters a laboratory or manufacturing workflow.

Reference: PubChem, “2,4-Difluorophenylboronic acid,” National Center for Biotechnology Information, PubChem database. Always verify the current record and supplier documentation before use.

2. Properties Relevant to Evaluation

Physical and Chemical Reference Points

The formula and molecular weight above are useful for calculating theoretical quantities, preparing stock solutions, and checking purchasing records. For example, a theoretical 1.00 mmol amount corresponds to approximately 157.91 mg before correcting for actual assay, water content, residual solvents, or other batch-specific factors. A 10.00 mmol calculation would correspond to approximately 1.579 g on the same theoretical basis, but the weighed amount should be adjusted according to the current CoA when an accurate stoichiometric charge is required.

Appearance, melting behavior, assay, water content, residual solvents, and impurity limits can vary by supplier specification, manufacturing route, storage history, and test method. I therefore avoid treating an online catalog value as a universal specification. The current CoA should identify the tested batch, analytical method, result, and acceptance criterion where applicable.

Solubility, Stability, and Compatibility

Solubility should be assessed in the actual solvent system used for the project rather than assumed from the compound name. The boronic acid group can participate in equilibria involving water, alcohols, bases, and other reaction components, while the fluorinated aromatic ring can influence electronic behavior in a target transformation. These general chemical considerations do not establish a guaranteed solubility profile, reaction yield, or shelf life for a specific lot.

For method development, I normally evaluate dissolution, reaction conversion, impurity formation, and isolation behavior at the intended concentration and temperature. Relevant analytical tools may include HPLC, LC-MS, NMR, or another validated method selected by the laboratory. Any reported purity or stability conclusion should be tied to a defined test method, sample, date, and acceptance criterion.

Reference: The International Council for Harmonisation (ICH) provides internationally recognized guidance for pharmaceutical analytical and stability work, including the importance of defined methods and documented conditions. See the ICH Quality Guidelines for general quality-system context.

3. Uses and Application Context

I generally position 2,4-difluorophenylboronic acid as an intermediate or research reagent for synthetic chemistry. A common evaluation route is a Suzuki-type cross-coupling with a chemically compatible aryl or heteroaryl halide, although the suitability of that reaction depends on the substrate, catalyst, base, solvent, temperature, concentration, and work-up procedure. The material should not be described as a finished drug, agrochemical active ingredient, or approved formulation component unless separate evidence supports that specific claim.

Pharmaceutical and Medicinal Chemistry Research

Medicinal chemistry teams may assess this compound when they need to introduce a difluorinated aromatic fragment into a candidate molecule. The fluorine substitution pattern can be relevant to structure–activity relationship exploration, but the value of the building block depends on the target structure and downstream chemistry. I recommend small-scale experimental screening before committing to larger quantities or a fixed process route.

Agrochemical and Specialty Chemical Research

Agrochemical and specialty chemical researchers may also consider aryl boronic acids as modular inputs for preparing more complex molecules. Suitability depends on route design, regulatory requirements, impurity control, reaction economics, and the final application. No single building block should be assumed to provide universal conversion, selectivity, or scale-up performance.

For project evaluation, I review at least five technical variables: substrate compatibility, catalyst and base selection, solvent system, target assay, and impurity profile. I also examine whether the boronic acid is stable enough for the planned storage and charging operations. ACS educational resources on palladium-catalyzed cross-coupling provide useful background, but project-specific performance still requires controlled laboratory testing.

Reference: See the American Chemical Society’s educational and technical resources on cross-coupling chemistry at ACS.org. Reaction conditions must be selected and validated by the responsible technical team.

4. Handling and Storage

Receiving and Laboratory Handling

I recommend inspecting the container, label, seal, lot number, quantity, and visible condition at receipt. The material should be handled according to the current SDS and supplier label, with suitable ventilation, laboratory controls, and personal protective equipment selected through a site-specific risk assessment. Avoid unnecessary dust generation, direct skin or eye contact, and transfer practices that could contaminate the material or surrounding work area.

Before dispensing, I verify that the container identity matches the purchase order and that the lot remains within the supplier’s stated retest or expiry framework, when such information is provided. I use clean, compatible equipment and return the material to a tightly closed container after use. Any aliquot should retain the original identity, lot traceability, hazard information, and relevant date information.

Storage and Spill Response

Storage should follow the supplier’s recommended conditions rather than an assumed universal temperature or shelf life. I keep the material in a tightly closed, properly labeled container and protect it from avoidable moisture, contamination, heat, or light when the SDS or product documentation identifies those factors as relevant. Exact storage temperature, shelf life, and retest period should be confirmed from current product-specific information.

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For a spill, exposure event, or waste-disposal question, I follow the site’s EHS procedures and the SDS rather than relying on a generic internet instruction. Personnel should isolate the area as appropriate, use authorized spill-response equipment, prevent uncontrolled release, and obtain medical or emergency assistance when required. Waste must be collected, labeled, and disposed of according to applicable institutional and local requirements.

Reference: OSHA’s Hazard Communication Standard, 29 CFR 1910.1200, explains the role of labels and SDSs in workplace chemical hazard communication. See the OSHA Hazard Communication resources; local requirements may differ.

5. Safety and Regulatory Considerations

I do not assign a definitive hazard classification to 2,4-difluorophenylboronic acid without reviewing the current product-specific SDS. Classification can depend on the product form, concentration, impurities, packaging, jurisdiction, and the regulatory data available at the time of shipment or use. A catalog description alone is not sufficient to determine hazard symbols, signal words, transport status, or regulatory obligations.

Before purchase or shipment, I request the latest SDS, product label information, CoA, lot details, and any available transport documentation. The procurement and EHS teams should check chemical inventory requirements, import or export controls, institutional approvals, workplace exposure procedures, and waste rules in the destination jurisdiction. These checks are particularly important when the material crosses national borders or is introduced into a regulated development environment.

Documentation should be reviewed before the first receipt, after any significant supplier change, and whenever the intended scale or use changes. If the material is used in a pharmaceutical, agrochemical, or other regulated development program, the project team should define its own qualification, change-control, analytical, and record-retention requirements. Supplier documentation supports compliance review but does not replace the buyer’s internal assessment.

6. Types, Material Options, and Specification Review

For this compound, “material options” usually refer to differences in grade, assay target, packaging size, analytical documentation, and supply form rather than different chemical identities. I distinguish the exact CAS 144025-03-6 material from related isomers, boronate esters, and substituted aromatic alternatives. Each option should be assessed against the intended reaction and the project’s documentation requirements.

These five review groups help separate a technically suitable product from a listing that merely matches a keyword. If a project has a narrow impurity limit or a validated process, I request a representative sample or qualification batch before scale-up. All specifications should be agreed in writing with the supplier before a purchase order is released.

7. Pricing, MOQ, Lead Time, and Supplier Evaluation

Pricing for 2,4-difluorophenylboronic acid may depend on quantity, target specification, packaging, documentation, production status, destination, and shipping requirements. I do not assume that a low unit price represents the lowest total procurement cost because additional testing, special packaging, customs handling, or qualification work may affect the project budget. Minimum order quantity and lead time must be quoted for the requested specification and destination.

When evaluating Maison Chemical or another supplier, I recommend asking whether the quotation covers the exact CAS number, requested purity, quantity, packaging, and documentation package. I also ask how the supplier manages lot traceability, retest or expiry information, storage before dispatch, and notification of specification or manufacturing changes. These questions help procurement and technical teams compare offers on more than price alone.

Recommended Supplier Enquiry Information

1. Compound name and CAS No.: 2,4-Difluorophenylboronic acid, 144025-03-6.
2. Required quantity and target purity or assay.
3. Packaging format and whether a sample or qualification batch is needed.
4. Delivery destination, preferred shipping schedule, and any import documentation needs.
5. Required documents, including the current SDS, CoA, lot traceability, and available retest or expiry information.

A complete enquiry allows us to check availability, possible lead time, packaging options, documentation, and commercial terms without making an unsupported commitment. For route development, I also encourage buyers to share the intended application at a suitable level so the technical discussion can focus on compatibility and qualification needs.

8. Frequently Asked Questions

What is 2,4-difluorophenylboronic acid?

It is a fluorinated aryl boronic acid containing fluorine substituents at the 2- and 4-positions of the phenyl ring. It is commonly considered a synthetic building block or research reagent.

What is the CAS number of the compound?

The CAS number is 144025-03-6. I recommend checking the CAS number together with the structure, formula, molecular weight, and supplier catalog data to avoid confusion with positional isomers.

What is it commonly used for?

It may be evaluated for boronic-acid-compatible transformations, including Suzuki-type cross-coupling in suitable reaction systems. Conversion, selectivity, scale-up behavior, and impurity formation must be confirmed experimentally for each route.

Which documents should I request before purchase?

I recommend requesting the current CoA, SDS, product label information, lot number, packaging details, retest or expiry information when applicable, and available shipping or transport documentation. Buyers should also confirm the agreed specification and commercial terms in writing.

How should handling and storage requirements be confirmed?

Use the latest product-specific SDS and supplier label as the primary references, then apply the site’s EHS risk assessment and operating procedures. Do not infer an exact storage temperature, shelf life, hazard classification, or transport status without current supporting documentation.

9. Conclusion and Next Steps

2,4-Difluorophenylboronic acid, CAS 144025-03-6, is an aryl boronic acid building block that may support pharmaceutical, agrochemical, and specialty chemical research when its identity, specification, and reaction suitability are confirmed. The most important procurement controls are accurate identity verification, current batch documentation, appropriate handling information, and a clear agreement on quantity, purity, packaging, destination, and delivery requirements. Its performance should be demonstrated in the intended reaction system rather than guaranteed from general chemical descriptions.

For a quotation or technical enquiry, contact Maison Chemical with the requested quantity, target purity, packaging preference, delivery destination, and required documents. We can review the enquiry for potential availability, lead-time information, sample or qualification-batch requirements, SDS and CoA documentation, and applicable commercial terms. Any final specification, shipment condition, price, and delivery commitment should be confirmed in the formal supplier quotation.

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