Aug. 11, 2026
Chemicals
4-Chlorophenylboronic acid CAS 1679-18-1 is primarily used as a boronic acid building block in palladium-catalyzed Suzuki–Miyaura cross-coupling reactions. In this reaction, its aryl-boron group can couple with an aryl or vinyl halide to help form a new carbon–carbon bond. I supply it as a research and process intermediate for pharmaceutical, agrochemical, materials, and fine-chemical development, subject to the buyer’s required specification and regulatory review.
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The compound has the molecular formula C6H6BClO2, a molecular weight of approximately 156.37 g/mol, and CAS Registry Number 1679-18-1. Its para-chloro substituent and boronic acid functionality provide two useful reaction features: the boronic acid group supports cross-coupling, while the chlorine atom can remain as part of the target structure or participate in further synthetic planning. Its exact suitability depends on the reaction route, catalyst system, impurity profile, and final application.
The most established use of 4-chlorophenylboronic acid is as an aryl donor in Suzuki–Miyaura coupling. Under a suitable catalytic system, the boronic acid group reacts with an organic halide or related electrophile to produce a biaryl or substituted alkene structure. This makes the material useful when a process chemist needs to introduce a 4-chlorophenyl group into a more complex molecule.
The reaction is not automatic and should not be treated as a universal one-pot solution. Catalyst selection, base, solvent, temperature, substrate structure, water content, and reaction concentration can all affect conversion and impurity formation. The American Chemical Society identifies Suzuki coupling as a major method for constructing carbon–carbon bonds through organoboron reagents, supporting this application context.
Source: American Chemical Society, “Suzuki Reaction,” Organic Chemistry Portal and ACS educational resources.
I also see 4-chlorophenylboronic acid used as an intermediate during medicinal chemistry and process chemistry programs. It may be incorporated into a candidate molecule, used to prepare an analog series, or evaluated as one component in a route-screening campaign. In these settings, the material is usually a means of building a target structure rather than the final active ingredient.
Because the compound contains both a boronic acid group and a chloro-substituted aromatic ring, it can support route diversification. A development team may compare it with other substituted phenylboronic acids to investigate electronic effects, steric effects, reaction selectivity, or downstream purification behavior. The actual value is therefore determined by the complete synthetic route, not by the name of the intermediate alone.
Pharmaceutical researchers may use CAS 1679-18-1 to prepare biaryl-containing compounds, heterocycle-substituted aromatics, and screening libraries. The product can be relevant during discovery chemistry, route scouting, impurity investigation, and process development. It should not be described as a pharmaceutical active ingredient unless the buyer’s specific regulatory documentation supports that classification.
For early-stage work, researchers may prioritize package size, delivery speed, analytical documentation, and suitability for parallel experiments. For scale-up, the priorities normally shift toward batch-to-batch consistency, trace-metal control, water content, residual solvents, packaging, and supply continuity. I recommend confirming these requirements before selecting a commercial grade.
The same cross-coupling chemistry can be used in the preparation of substituted aromatic structures relevant to agrochemical and specialty chemical research. A 4-chlorophenyl fragment may be retained in the final molecule or used as a functional handle for subsequent transformations. The exact role depends on the target structure and the reaction sequence selected by the development team.
Organoboron chemistry is also used in the preparation of functional molecules, ligands, and advanced organic materials. In this context, 4-chlorophenylboronic acid can serve as a controlled aromatic building block for laboratory-scale synthesis. Its use in a materials project should be validated through route-specific testing because coupling performance may vary substantially with the other reactants and catalyst conditions.
Research-grade material is generally selected for discovery experiments, method development, and small-scale synthesis. Buyers commonly request identity confirmation, assay information, batch number, and an analytical certificate. This option may be appropriate when the immediate requirement is experimental access rather than long-term process supply.
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Process-development material requires a more detailed quality discussion. I typically recommend reviewing assay, related substances, water content, residual solvents, inorganic residues, and potentially palladium or other elemental impurities when the compound will enter a metal-catalyzed process. The target limits should be agreed between the buyer and supplier instead of assumed from a catalog description.
For recurring demand, buyers may need customized packaging, particle-size guidance, production scheduling, or a defined analytical package. Custom support is useful when the material will be used across multiple development batches or when a customer has an internal specification. Availability, minimum order quantity, and lead time should be confirmed for each order rather than presented as fixed universal values.
| Specification area | Why it matters |
|---|---|
| CAS number | Confirms that the requested substance is CAS 1679-18-1. |
| Molecular formula | C6H6BClO2; useful for route calculations and documentation. |
| Molecular weight | Approximately 156.37 g/mol; used for stoichiometric calculations. |
| Assay and related substances | Helps assess reaction input quality and impurity risk. |
| Water content | Important because moisture can influence reagent handling and reaction reproducibility. |
| Elemental impurities | Relevant when the material will be used in a metal-catalyzed or regulated development process. |
| Packaging and storage | Should be matched to the buyer’s handling, transport, and shelf-life requirements. |
Public chemical databases list the identity information for 4-chlorophenylboronic acid, including its CAS number, molecular formula, and molecular weight. Physical appearance, melting behavior, storage instructions, and hazard communication should be confirmed from the supplier’s current specification sheet and Safety Data Sheet because commercial specifications and handling recommendations can differ.
Source: PubChem, National Center for Biotechnology Information, Compound Summary for 4-Chlorophenylboronic acid, CID 2734257.
For a reaction screen involving 10–100 mg, a documented research pack may be sufficient. A route-development project using gram or kilogram quantities requires additional discussion of batch consistency, analytical methods, packaging, and supply planning. I advise buyers to define the intended scale before requesting a quotation because the most economical package is not always the most suitable package.
Start with the attributes that can influence the reaction or downstream purification. These may include assay, related substances, water content, residual solvents, insoluble matter, and trace metals, with numerical acceptance limits agreed in advance. If a buyer has a validated method, sharing the method or reporting format can reduce misunderstanding during qualification.
A high assay value alone does not guarantee identical performance in every Suzuki coupling. The electrophile, base, ligand, palladium source, solvent, temperature, and concentration can all affect the result. For a critical route, I recommend a small-scale confirmation experiment using the proposed production batch before committing to a larger procurement plan.
At Maison Chemical, I support buyers who need 4-chlorophenylboronic acid CAS 1679-18-1 for pharmaceutical intermediate research, fine-chemical synthesis, and process development. Our discussion can cover the requested quantity, target specification, packaging format, analytical documents, delivery location, and intended use. Where a standard product specification does not meet the project requirement, the buyer should provide the relevant quality parameters so that feasibility can be assessed accurately.
I can also help organize a quotation around practical B2B requirements, including sample quantities, repeat-order planning, documentation review, and shipment coordination. I do not recommend selecting a supplier solely by unit price because assay, impurity control, packaging, lead time, and documentation can influence the total project cost. Final supply terms remain subject to product availability, technical review, and applicable compliance requirements.
4-Chlorophenylboronic acid CAS 1679-18-1 is used mainly to introduce a 4-chlorophenyl group into more complex molecules through Suzuki–Miyaura and related synthetic chemistry. Its principal commercial value is as a reliable building block for pharmaceutical intermediate development, agrochemical research, fine chemicals, and selected materials applications. The correct grade depends on the reaction scale, impurity requirements, documentation needs, and expected supply frequency.
As a next step, prepare your required quantity, target assay, impurity limits, packaging preference, delivery location, and intended application. Send these details to Maison Chemical for a practical quotation and technical supply review for 4-Chlorophenylboronic acid CAS 1679-18-1.
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