Sep. 29, 2026
Chemicals
I use 3,4-Difluoro-2-methoxyphenylboronic acid, CAS 905583-06-4, as a specialized boronic acid building block for research and development programs that require a fluorinated, methoxy-substituted aromatic fragment. Its primary value is its participation in palladium-catalyzed Suzuki–Miyaura coupling with suitable aryl or heteroaryl halides. For purchasing decisions, I recommend evaluating identity, assay, water content, residual solvents, packaging, documentation, and supply continuity rather than relying on the chemical name alone.
This guide is written for pharmaceutical and agrochemical researchers, process development teams, procurement professionals, and technical decision-makers. It explains what the compound is used for, which specifications should be confirmed, how to compare supplier offers, and how Maison Chemical can support an efficient inquiry. Because commercial specifications can vary by batch and application, I treat the values below as reference points rather than a substitute for a current certificate of analysis.
This guide is intended for buyers sourcing a small-molecule intermediate for laboratory synthesis, route scouting, medicinal chemistry, process research, or custom development. It is also useful for teams comparing catalog material with a project-specific supply arrangement. I recommend involving both procurement and technical reviewers because a low unit price may not compensate for unsuitable packaging, insufficient analytical data, or an uncertain lead time.
3,4-Difluoro-2-methoxyphenylboronic acid is an organoboron compound containing an aromatic boronic acid group, two fluorine substituents, and one methoxy substituent. The listed CAS number is 905583-06-4, and the commonly referenced molecular formula is C7H7BF2O3, with an approximate molecular weight of 187.94 g/mol. These identifiers are useful for initial screening, but I still advise confirming the structure by analytical data before using the material in a critical synthesis.
The boronic acid functionality is the key reactive handle. Under appropriate reaction conditions, it can be coupled with aryl, heteroaryl, or vinyl halides to form a new carbon–carbon bond, while the fluorine and methoxy groups remain part of the resulting molecular architecture. Actual reaction performance depends on the coupling partner, catalyst system, base, solvent, temperature, concentration, and work-up procedure.
In medicinal chemistry, this compound can serve as a modular aromatic fragment for preparing analogues that incorporate both fluorine and methoxy substitution. Fluorine atoms are often introduced during molecular design to investigate changes in lipophilicity, metabolic behavior, conformation, or electronic properties, but the effect must be assessed for each chemical series. The compound is therefore best viewed as a versatile research intermediate rather than as a finished active pharmaceutical ingredient.
Process chemists may evaluate this boronic acid when a target structure requires a substituted biaryl or heterobiaryl connection. During route scouting, I recommend testing a small range of catalyst and base systems because boronic acids can show different behavior depending on electronic and steric effects. A route that works at milligram scale may require additional optimization before it is considered suitable for larger laboratory or pilot quantities.
Custom synthesis providers may use CAS 905583-06-4 as an input for preparing more complex intermediates. Its value is highest when the downstream target specifically benefits from the 3,4-difluoro-2-methoxyphenyl motif. If the project does not require this substitution pattern, an alternative boronic acid or boronate ester may offer a simpler or more economical route.
Buyers should first confirm whether they need the free boronic acid or a related protected boronate ester. These forms are not automatically interchangeable because they can differ in stability, handling, solubility, and reaction behavior. For a request involving 3,4-Difluoro-2-methoxyphenylboronic acid, I ask the supplier to state the exact chemical form, salt or solvate status if applicable, and intended shipment form.
| Specification area | What I recommend confirming | Why it matters |
|---|---|---|
| Identity | CAS number, molecular formula, structure, and analytical identity | Prevents confusion with positional isomers or related boronate products |
| Assay and purity | Current batch result and test method | Supports reaction planning and impurity control |
| Water and solvents | Water content and residual solvent information where relevant | Moisture and volatile residues can affect weighing and coupling conditions |
| Physical form | Appearance, storage temperature, packaging, and handling notes | Helps the receiving team plan safe and consistent use |
I do not recommend publishing or accepting a fixed purity value without a batch-specific analytical document. For example, a supplier may offer different grades for screening, research, or process use, and the relevant acceptance criteria may not be identical. Ask for the latest certificate of analysis, chromatographic data when available, and a clear statement of which results are specification limits versus actual batch results.
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Start with the complete name, CAS 905583-06-4, required quantity, intended use, and target delivery location. If your route uses Suzuki–Miyaura coupling, provide the approximate scale and any known sensitivity to moisture or residual solvents. I also recommend confirming whether your team requires research-use material, process-development material, or a specification aligned with an internal quality system.
A serious supplier response should identify the product unambiguously and provide practical documentation for evaluation. At minimum, I look for a specification sheet or certificate of analysis, batch or lot identification, test date, storage guidance, and packaging information. Additional documents may be appropriate depending on the project, but they should be requested according to actual regulatory and quality requirements rather than assumed.
Compare price together with quantity breaks, minimum order quantity, packaging, shipping conditions, payment terms, and estimated lead time. A quotation that appears inexpensive may become less competitive if it requires a large minimum quantity or has an extended production schedule. For early research, I generally suggest starting with the smallest quantity that supports meaningful route evaluation, then discussing larger supply after the chemistry is confirmed.
Supply continuity is especially important when a building block becomes part of a validated or semi-optimized route. Ask whether the offered material is regularly produced, made to order, or available only from limited stock. I also recommend asking how the supplier handles specification changes, repeat orders, packaging revisions, and pre-shipment document review.
The commercial price of this type of specialty intermediate can vary with purity requirements, order quantity, synthesis route, packaging, analytical testing, and shipping destination. I do not present an artificial fixed price because a reliable quotation requires project-specific information. A buyer requesting 1 g for screening may receive very different terms from a buyer requesting 100 g for process research.
Lead time should also be treated as an item to confirm rather than a universal product attribute. Stock availability, production scheduling, quality release, export documentation, and destination requirements can each affect delivery. When planning a campaign, I recommend requesting both the current availability and the estimated repeat-order lead time, expressed in business days or another clearly defined time unit.
Maison Chemical supports B2B inquiries for 3,4-Difluoro-2-methoxyphenylboronic acid as a manufacturer, supplier, and exporter of pharmaceutical intermediates and specialty chemical building blocks. I can help buyers organize product identity, requested quantity, technical documentation, packaging, and delivery requirements before a quotation is prepared. Final availability, specification, price, MOQ, and lead time should be confirmed directly for the requested batch and destination.
3,4-Difluoro-2-methoxyphenylboronic acid CAS 905583-06-4 is a specialized aromatic boronic acid used mainly as a coupling intermediate in research and development chemistry. Its practical suitability depends on more than the chemical name: buyers should confirm the exact form, analytical identity, purity basis, moisture information, packaging, and supply terms. The approximate molecular weight is 187.94 g/mol, while commercial acceptance criteria must be verified from current batch documentation.
My recommended next step is to send Maison Chemical your required quantity, application stage, target specification, delivery location, and documentation needs. We can then evaluate the appropriate supply option and provide a quotation based on the actual project requirements. This approach gives procurement and technical teams a clearer basis for comparing quality, cost, lead time, and long-term sourcing risk.
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