4-Tolylboronic Acid CAS 5720-05-8: Uses, Properties, Specifications, and Buying Guide

4-Tolylboronic acid, also called 4-methylphenylboronic acid or p-tolylboronic acid, is an aromatic boronic acid used mainly as a coupling partner in organic synthesis. Its CAS number is 5720-05-8, its molecular formula is commonly listed as C₇H₉BO₂, and its molecular weight is approximately 135.96 g/mol. I recommend it for research, pharmaceutical-intermediate development, agrochemical synthesis, and other projects requiring the introduction of a 4-methylphenyl group. As Maison Chemical, we help buyers confirm identity, grade, packaging, documentation, and supply feasibility before purchase.

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Who This Guide Is For

I prepared this guide for procurement teams, process chemists, laboratory managers, contract manufacturers, and R&D scientists evaluating 4-Tolylboronic acid CAS 5720-05-8. It is especially useful when a buyer needs to compare suppliers rather than simply locate a catalog listing. The guide covers the compound’s basic identity, common uses, specification considerations, sourcing factors, and practical supplier checks.

This material may be purchased for milligram- or gram-scale discovery work, kilogram-scale process development, or recurring manufacturing programs. The correct purchasing decision depends on the reaction, required purity, analytical documentation, expected consumption, and delivery schedule. I therefore recommend treating the product specification and project requirements as equally important.

Basic Concept and Chemical Context

4-Tolylboronic acid contains a boronic acid group attached to a benzene ring bearing a methyl substituent in the para position. In a typical palladium-catalyzed Suzuki–Miyaura coupling, the arylboronic acid reacts with an appropriate halide or related electrophile to form a new carbon–carbon bond. This makes the compound a practical building block for preparing substituted biaryl and aryl-containing molecules.

The boronic acid group is chemically useful but can also be sensitive to storage conditions, moisture exposure, and prolonged handling. Commercial appearance is often described as a white to off-white solid, but the actual appearance should be confirmed against the supplier’s current certificate of analysis. I do not advise using color alone as proof of identity or purity.

Identity and Reference Data

Common Uses and Application Matching

Suzuki–Miyaura Coupling

The most established use of 4-Tolylboronic acid is as an aryl donor in Suzuki–Miyaura cross-coupling. It can provide a 4-methylphenyl fragment when paired with a suitable aryl, heteroaryl, or vinyl electrophile under an appropriate catalytic system. The exact yield and selectivity depend on the reaction substrate, catalyst, base, solvent, temperature, concentration, and work-up procedure.

I recommend that development teams evaluate the compound using their actual substrate rather than assuming that a successful literature reaction will transfer directly to production. Heteroaryl substrates, sterically hindered partners, and scale-up conditions may require different catalyst loading or process controls. A supplier can provide consistent material, but the reaction protocol still requires customer-side validation.

Pharmaceutical and Agrochemical Intermediate Research

4-Tolylboronic acid can be used to construct intermediates containing a para-methyl-substituted aromatic ring. Such intermediates may appear in medicinal chemistry programs, compound libraries, agrochemical research, and specialty organic synthesis. The compound is generally a building block rather than a finished active ingredient, so its value is determined by how effectively it supports the buyer’s target synthesis.

Process Development and Custom Synthesis

In process chemistry, the material may be evaluated during route scouting, impurity studies, or preparation of an advanced intermediate. Buyers should define whether they need a standard research grade, a tighter impurity profile, or a production-oriented specification. I suggest confirming the required scale, analytical method, residual solvent limits, and packaging before requesting a commercial quotation.

Types, Grades, and Specification Options

Not every purchase requires the same level of specification. A discovery laboratory may prioritize availability and a reliable assay, while a manufacturing program may require batch-to-batch consistency, traceability, controlled packaging, and a defined impurity profile. Maison Chemical can discuss the intended application so that the offered specification is aligned with the actual use rather than unnecessarily broad or restrictive.

A purity target of 98% or higher is commonly requested for research-grade aryl boronic acids, but this should be treated as a purchasing specification rather than an automatic property of every lot. I advise buyers to request the current batch-specific certificate of analysis and confirm how the assay is calculated. If the material will enter a regulated or tightly controlled process, additional tests may be necessary.

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Buyer Selection Framework

1. Define the Reaction Requirement

First, I identify how the material will be used and which impurities could affect the reaction. For a Suzuki coupling, the buyer may need to consider unreacted starting material, inorganic residues, moisture, and trace metals. A clear application description helps the supplier recommend a suitable grade and avoids selecting a specification that does not address the actual process risk.

2. Confirm Analytical Evidence

I recommend requesting identity and purity information before placing a larger order. Depending on the supplier’s standard documentation, this may include chromatographic purity, spectroscopic identification, water or loss-on-drying information, and batch traceability. Buyers should distinguish between a generic product page and a batch-specific certificate prepared for the supplied lot.

3. Review Packaging and Storage

Because boronic acids can be affected by environmental exposure, packaging should be discussed as part of the technical review. The buyer should confirm container size, inner packaging, labeling, transport conditions, and recommended storage instructions. I do not recommend transferring the material into an unmarked container or leaving it exposed during repeated laboratory use.

4. Match Quantity to the Project

Small quantities may be appropriate for route scouting, while larger quantities require a more detailed supply plan. Ask whether the quoted quantity is available from stock, produced to order, or subject to a production schedule. MOQ and lead time are supplier- and order-dependent, so Maison Chemical confirms these items case by case rather than presenting unsupported fixed promises.

Pricing, MOQ, and Lead-Time Considerations

The price of 4-Tolylboronic acid CAS 5720-05-8 can vary with purity target, order quantity, packaging, testing requirements, and delivery destination. A small laboratory pack may have a higher unit cost than a larger project quantity because of handling and documentation overhead. For a fair comparison, I recommend asking suppliers to quote the same quantity, specification, Incoterm, packaging format, and documentation package.

MOQ may differ between samples, regular catalog supply, and custom production. Lead time may also change according to inventory status, batch release, production capacity, and export arrangements. Maison Chemical can review the requested quantity and destination, then provide a practical quotation with availability and proposed delivery timing.

Supplier Evaluation Checklist

• Does the supplier clearly identify the product as CAS 5720-05-8?
• Can the supplier provide a batch-specific certificate of analysis?
• Is the stated purity supported by a defined analytical method?
• Are packaging, labeling, storage, and shipping conditions explained?
• Can the supplier support both development quantities and larger repeat orders?
• Are MOQ, lead time, payment terms, and delivery conditions stated in the quotation?
• Can the supplier discuss custom specifications without making unsupported claims?

I also recommend checking communication quality during the quotation stage. A supplier that asks about application, quantity, specification, and destination is more likely to understand the practical requirements of a B2B order. However, good communication does not replace technical verification; the final decision should remain based on documented product and supply information.

Maison Chemical Supply Support

At Maison Chemical, I support buyers evaluating 4-Tolylboronic acid for laboratory research, process development, and commercial sourcing. We can discuss product identity, requested purity, packaging, documentation, quantity, and delivery requirements before confirming an order. Our role is to help create a clear specification and sourcing plan, not to make unverified claims about performance in a customer’s reaction.

When you contact us, please include the required quantity, target purity, intended application, preferred packaging, destination country, and desired delivery schedule. If you have an internal specification or analytical method, sharing it can make the quotation more accurate. We can then assess the request and respond with available supply options, documentation details, MOQ, lead time, and commercial terms.

Key Takeaways

• 4-Tolylboronic acid CAS 5720-05-8 is an aryl boronic acid used primarily to introduce a 4-methylphenyl group in organic synthesis.
• Its commonly listed molecular formula is C₇H₉BO₂, with an approximate molecular weight of 135.96 g/mol.
• Suzuki–Miyaura coupling is a major application, but reaction performance must be validated with the buyer’s specific substrate and process.
• Purity, analytical method, packaging, storage, documentation, MOQ, and lead time should all be confirmed before purchase.
• Maison Chemical can support specification review and B2B quotation requests for project-specific requirements.

Conclusion: How to Buy with Greater Confidence

If you need an aromatic boronic acid for preparing a para-methyl-substituted aryl product, 4-Tolylboronic acid CAS 5720-05-8 is a relevant building-block option. The best purchase is not determined by name and price alone; it depends on verified identity, suitable purity, batch documentation, appropriate packaging, and dependable supply planning. I recommend starting with your reaction and quality requirements, then comparing suppliers using the same commercial and technical criteria.

For the next step, send Maison Chemical your required quantity, purity target, application, packaging preference, destination, and delivery date. We will review the request and provide the most suitable available supply information for your project.

The company is the world’s best 4-Tolylboronic acid CAS 5720-05-8 supplier. We are your one-stop shop for all needs. Our staff are highly-specialized and will help you find the product you need.