Sep. 15, 2026
Chemicals
If you are sourcing 3,5-Difluorophenylboronic acid, CAS 156545-07-2, you are typically looking for a fluorinated aryl boronic acid used as a building block in palladium-catalyzed cross-coupling chemistry, especially Suzuki–Miyaura reactions. I identify this material by its CAS number, chemical name, molecular formula C6H5BF2O2, and reported molecular weight of approximately 157.91 g/mol. At Maison Chemical, I support B2B buyers by helping them confirm identity, grade, documentation, packaging, quantity, and delivery requirements before quotation.
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This guide explains how I recommend evaluating the material, matching it to an application, comparing supplier offers, and reducing avoidable sourcing risk. Because commercial specifications can vary by manufacturer and intended use, I advise buyers to confirm the current specification and certificate of analysis for every batch rather than relying only on a catalog description.
I prepared this guide for pharmaceutical and agrochemical research teams, medicinal chemistry laboratories, specialty chemical manufacturers, procurement departments, and distributors that need a reliable source of 3,5-Difluorophenylboronic acid. It is also relevant to organizations planning scale-up from laboratory synthesis to process development. The guide is useful whether you are purchasing a small research quantity or evaluating a recurring B2B supply program.
Buyers should distinguish between an initial compound-screening requirement and a regulated or production-related requirement. The first may focus on identity, purity, and fast availability, while the second usually requires stronger control of documentation, batch consistency, packaging, change notification, and logistics. I recommend defining that use case before requesting quotations.
3,5-Difluorophenylboronic acid is an aryl boronic acid containing a phenyl ring substituted with fluorine atoms at the 3 and 5 positions and a boronic acid functional group. Its boron-containing group can participate in carbon–carbon bond-forming reactions with suitable aryl or heteroaryl halides under appropriate catalytic and reaction conditions. The exact reaction performance depends on the reaction partners, solvent, base, catalyst system, temperature, and work-up process.
The compound is commonly considered a synthetic intermediate rather than a finished active ingredient. Its value comes from combining an aryl boronic acid coupling handle with two fluorine substituents, which can help chemists introduce a defined fluorinated aromatic fragment into a target molecule. I do not treat the presence of fluorine as a guarantee of better biological performance; that conclusion must be established for each specific molecular program.
Before I prepare a commercial offer, I encourage buyers to confirm the information needed for technical approval. The core identity data normally includes the product name, CAS number 156545-07-2, molecular formula C6H5BF2O2, and molecular weight approximately 157.91 g/mol. Buyers should also confirm whether the requested grade is intended for research, process development, or another controlled application.
| Item to Review | Why It Matters |
|---|---|
| Identity and CAS number | Reduces the risk of ordering a positional isomer or similarly named fluorinated intermediate. |
| Assay or purity specification | Helps the technical team assess suitability for screening, synthesis, or scale-up. |
| Water and residual solvent data | May affect reaction reproducibility and material balance in sensitive processes. |
| Appearance and analytical method | Provides a practical basis for incoming inspection and batch comparison. |
| Packaging and storage guidance | Supports appropriate handling during transport and warehouse storage. |
I recommend requesting a current certificate of analysis, safety data sheet, batch or lot information, and available analytical data such as HPLC, NMR, or other suitable identity and purity records. These documents should be reviewed against the buyer’s internal quality requirements. If a project has a defined impurity profile or analytical method, I advise sharing those requirements before order confirmation.
In medicinal chemistry, I commonly position this compound as a building block for preparing analogues that contain a difluorinated phenyl group. A chemist may use it in a coupling sequence to connect the aromatic fragment with a halogenated partner. The suitability of the material still depends on the complete reaction design and the customer’s purification strategy.
For process development, buyers usually need more than a product name and nominal purity. They may need repeatable batch quality, clear packaging information, dependable documentation, and a supply plan that can support multiple development stages. I recommend evaluating not only the first delivery but also the supplier’s ability to discuss future quantities and specification continuity.
Organizations running parallel synthesis may value clear stock communication and consistent lot documentation. When many reactions are planned, even a small difference in impurity level, water content, or physical handling can influence downstream work. I advise teams to establish an incoming inspection procedure and retain a reference sample according to their internal policy.
I use a five-part framework when helping buyers compare suppliers: identity, quality, documentation, supply capability, and commercial fit. Identity confirms that the requested compound is the correct 3,5-substituted isomer. Quality covers the agreed assay and relevant impurity or analytical requirements, while documentation demonstrates whether the material can pass the customer’s approval process.
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Price should be evaluated together with usable quality and delivery reliability. A lower unit price may not be advantageous if the product requires additional qualification, arrives outside the project schedule, or lacks the documentation required for release. I therefore recommend comparing total procurement risk rather than using price as the only decision factor.
Pricing for 3,5-Difluorophenylboronic acid can vary according to quantity, grade, packaging, production status, analytical requirements, destination, and shipping terms. I avoid presenting a universal price because a research pack and a recurring industrial quantity are not commercially equivalent. The most accurate quotation requires the requested quantity, destination country, packaging preference, and documentation requirements.
MOQ is also supplier- and project-dependent. Some buyers need a small quantity for route evaluation, while others require a larger planned shipment for development or distribution. I recommend asking whether the quoted quantity is available from current stock or requires production, because this distinction can affect lead time and shipment planning.
Lead time should be confirmed in writing and linked to the specific quantity and specification. Buyers should also consider transit time, export documentation, customs procedures, and any temperature or handling requirements identified in the applicable safety documentation. At Maison Chemical, I use the customer’s actual purchasing scenario to determine the most appropriate supply discussion rather than giving an unsupported standard promise.
Similar names can refer to different fluorinated phenylboronic acid isomers. I recommend checking the CAS number, molecular formula, structure, and analytical documentation together. This simple verification step helps reduce the risk of using the wrong positional isomer in a research program.
A supplier suitable for a small laboratory order may not automatically be suitable for repeated development quantities. Buyers should clarify expected annual demand, delivery frequency, packaging, and change-control expectations at the beginning. This allows the supplier to assess the commercial fit more realistically.
Catalog information is useful for initial screening, but it should not replace batch-specific documentation when the project requires formal incoming inspection. I advise buyers to review the current COA and SDS before final approval. Where additional analytical data is necessary, that request should be included in the inquiry.
At Maison Chemical, I support sourcing conversations for 3,5-Difluorophenylboronic acid CAS 156545-07-2 with a practical focus on product identity, specification alignment, documentation, packaging, and export requirements. I can review the buyer’s intended application and help identify the information needed for a meaningful quotation. I also encourage buyers to state their required quantity, target purity, destination, and desired delivery schedule at the inquiry stage.
Our role is to connect the technical requirement with a workable supply plan. Where a buyer has internal quality forms, labeling requirements, or document expectations, I recommend sharing them early so the quotation can be evaluated on the correct basis. Any availability, MOQ, lead time, and product specification should be confirmed for the specific order rather than assumed from general market information.
My direct recommendation is to source 3,5-Difluorophenylboronic acid CAS 156545-07-2 through a documented specification review rather than a price-only comparison. First, define your application and quantity; then confirm identity, purity requirements, current batch evidence, packaging, and delivery terms. This approach gives your technical and procurement teams a clearer basis for approval.
If you are evaluating this material for a new synthesis, process development program, or recurring supply requirement, contact Maison Chemical with your target quantity, destination, specification, and documentation needs. I can then help you assess the appropriate supply route and prepare a B2B quotation based on your actual requirements.
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