What Is 4-Hydroxycyclohexanone Ethylene Acetal CAS 22428-87-1? Identity, Structure, and Uses

4-Hydroxycyclohexanone ethylene acetal, identified by CAS 22428-87-1, is a protected cyclohexanone intermediate containing both an ethylene acetal group and a secondary alcohol. I describe it chemically as 4-hydroxy-1,1-ethylenedioxycyclohexane, with the molecular formula C₈H₁₂O₃ and a calculated molecular weight of 156.18 g/mol. Its main value is functional-group control: the former ketone is protected as an acetal while the hydroxyl group remains available for further synthesis.

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At Maison Chemical, I position this material for research, process development, pharmaceutical-intermediate synthesis, and other applications that require a defined cyclohexane building block. The appropriate grade, packaging, analytical documentation, and shipping conditions should be confirmed against the buyer’s route and quality requirements. Because physical specifications can vary by production and handling conditions, I recommend using the current product specification and certificate of analysis for final purchasing decisions.

Identity and Chemical Structure

The name “4-hydroxycyclohexanone ethylene acetal” describes a cyclohexane ring in which the ketone functionality has been converted into a cyclic ethylene acetal. The acetal is formed from the carbonyl carbon and ethylene glycol, producing a five-membered 1,3-dioxolane ring fused through the same carbon to the cyclohexane framework. A hydroxyl group remains at the 4-position of the ring.

This structure combines two useful features in one molecule. The acetal masks the ketone during transformations that may otherwise react with or modify a carbonyl group, while the alcohol can participate in reactions such as oxidation, esterification, etherification, or other route-specific functionalization. I therefore view CAS 22428-87-1 as a multifunctional synthetic intermediate rather than as a final-use active ingredient.

Core Functions in Organic Synthesis

Carbonyl protection

The ethylene acetal serves as a protecting group for the original cyclohexanone carbonyl. In a multistep synthesis, this protection can help reduce unwanted carbonyl reactions while another part of the molecule is modified. The acetal is not intended to be permanently retained in every route; under suitable acidic hydrolysis conditions, it may be converted back to the corresponding ketone.

Retained hydroxyl reactivity

The 4-hydroxyl group provides a separate reaction handle. Depending on the process design, a chemist may convert it into an ester, ether, leaving group, oxidized derivative, or another substituted product. The correct transformation depends on reagent compatibility, selectivity, solvent, temperature, and the stability of the acetal under the selected conditions.

Route simplification

Using a pre-functionalized intermediate can reduce the number of operations required to introduce both a protected carbonyl equivalent and an alcohol. I do not treat this as a guarantee of higher yield or lower cost, because the overall benefit depends on the complete synthetic sequence. Buyers should compare the material’s analytical quality, conversion performance, process safety, and supply reliability with alternative starting materials.

Typical Application Scenarios

CAS 22428-87-1 may be used as a building block in pharmaceutical and medicinal chemistry programs where a substituted cyclohexane architecture is required. It can also be evaluated in process research for the preparation of more advanced intermediates containing ketone, alcohol, ether, ester, or other derived functionality. The compound’s usefulness is especially relevant when chemists need to differentiate the reactivity of a protected carbonyl site from that of a free hydroxyl group.

In discovery research, the material may support the preparation of small molecular libraries and route analogues. In process development, it may be considered as a defined intermediate for evaluating scale-up conditions, impurity control, isolation, and downstream deprotection. These are potential application scenarios rather than a claim that the compound is approved for a particular pharmaceutical product or regulatory use.

• Pharmaceutical intermediates: building-block evaluation for substituted cyclohexane compounds.
• Medicinal chemistry: preparation of analogues where controlled carbonyl and alcohol chemistry is useful.
• Process development: route scouting, reaction optimization, impurity assessment, and scale-up studies.
• Custom synthesis: starting material for further derivatization based on a buyer’s target structure.
• Research applications: laboratory and pilot work subject to the customer’s own validation and safety review.

Material Options and Specification Considerations

For this type of intermediate, “material option” usually refers to quantity, packaging, specification level, and documentation rather than different chemical isomers. Buyers may need laboratory quantities for route screening, larger quantities for process development, or repeat batches for manufacturing assessment. I recommend confirming whether the requested material is intended for discovery use, non-GMP process work, or a more controlled supply program before quotation.

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Important specification items may include assay or purity, water content, residual solvents, related substances, identification by analytical methods, and appearance. The exact acceptance limits should be agreed in a product specification rather than inferred from the chemical name alone. If stereochemical purity, trace metals, or a particular impurity profile is important to the route, those requirements should be stated before production or shipment.

Documents that support technical review

A responsible B2B evaluation normally includes a current specification sheet and certificate of analysis for the relevant batch. Depending on the order and destination, buyers may also request a safety data sheet, packaging information, transport classification, and basic storage guidance. I provide documentation according to the material and order requirements, but I do not suggest that a document replaces the buyer’s own qualification process.

How Buyers Should Select a Supplier

The first selection factor is identity confirmation. The CAS number, chemical name, molecular formula, and analytical identification should be consistent across the quotation, specification, label, and batch documentation. I also encourage buyers to confirm whether the supplier can provide a representative sample before committing to a larger quantity when the compound is being introduced into a new synthetic route.

The second factor is batch consistency. A useful supplier should be able to discuss control of starting materials, reaction conditions, work-up, purification, and packaging without making unsupported claims about performance. For recurring orders, buyers should ask how specifications are maintained between batches and how deviations or out-of-specification results are handled.

The third factor is commercial and logistical fit. Lead time, minimum order quantity, packaging format, export documentation, shelf-life information, and destination-country requirements can affect the real cost of procurement. I recommend comparing the delivered specification and service package—not only the price per kilogram—because a low initial price may not address analytical, documentation, or scheduling needs.

Maison Chemical Supplier Support

Maison Chemical supports B2B buyers seeking 4-Hydroxycyclohexanone ethylene acetal CAS 22428-87-1 for chemical and pharmaceutical-intermediate applications. I can help clarify the product identity, discuss the intended application, review requested specifications, and coordinate quotation details for the required quantity. For technical evaluation, I recommend sharing the target use, desired purity, packaging preference, destination, and any documentation requirements.

My approach is to keep the sourcing discussion specific and evidence-based. Rather than assuming that one specification fits every project, I work with buyers to identify the acceptance criteria that matter to their route and quality system. Availability, lead time, packaging, and batch documentation should be confirmed in the commercial quotation because they depend on order details and current supply conditions.

Key Takeaways

• 4-Hydroxycyclohexanone ethylene acetal is CAS 22428-87-1, also described as 4-hydroxy-1,1-ethylenedioxycyclohexane.
• Its molecular formula is C₈H₁₂O₃, and its calculated molecular weight is 156.18 g/mol.
• The cyclic ethylene acetal protects the ketone equivalent, while the 4-hydroxyl group remains available for further functionalization.
• Potential uses include pharmaceutical-intermediate synthesis, medicinal chemistry, process development, and custom chemical research.
• Buyers should verify assay, impurity profile, water, residual solvents, packaging, documentation, lead time, and intended-use requirements before ordering.

Conclusion and Next Steps

In direct answer to the question, 4-Hydroxycyclohexanone ethylene acetal CAS 22428-87-1 is a protected cyclohexanone-derived intermediate with a cyclic ethylene acetal and a free secondary alcohol. Its structure makes it useful for synthetic routes that require carbonyl protection together with a separately reactive hydroxyl group. The most appropriate application and specification depend on the buyer’s target molecule and process conditions.

As a next step, I recommend sending Maison Chemical the required quantity, target purity, application stage, destination, packaging preference, and documentation needs. I can then help determine the relevant supply format and provide current commercial information for evaluation. Before scale-up, buyers should review the batch documentation and confirm that the material meets their internal analytical and process requirements.

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