Who This Guide Is For

I prepared this guide for medicinal chemistry teams, pharmaceutical and agrochemical researchers, specialty chemical distributors, process development groups, and purchasing professionals sourcing organic boronic acids. It is also useful for laboratories that need a small quantity for reaction screening before moving toward larger-scale procurement. The goal is to connect technical requirements with practical supplier decisions.

4-Methoxyphenylboronic acid is usually purchased as a research or process intermediate rather than as a finished active ingredient. Because the appropriate grade depends on the reaction and downstream use, I suggest confirming the intended application before comparing quotations. A supplier may offer different packaging sizes, assay targets, documentation packages, or production arrangements for different customer requirements.

What Is 4-Methoxyphenylboronic Acid?

4-Methoxyphenylboronic acid is an aromatic boronic acid containing a methoxy-substituted phenyl group and a boronic acid functional group. The methoxy group is positioned at the para, or 4-, position relative to the boronic acid substituent. Its chemical name may also appear as 4-methoxybenzeneboronic acid or (4-methoxyphenyl)boronic acid in technical documents and procurement systems.

The material is commonly handled as a solid and may show limited water solubility, while compatibility with organic solvents depends on solvent selection, concentration, temperature, and the specific batch. I do not recommend selecting a solvent solely from a generic catalog description. For reaction development, users should verify dissolution and stability under their own operating conditions.

Uses and Application Scenarios

Suzuki–Miyaura Coupling

The best-known use of 4-Methoxyphenylboronic acid is as an aryl donor in Suzuki–Miyaura coupling. In a suitable catalytic system, the arylboronic acid can react with an aryl or vinyl halide, commonly a bromide, iodide, or related electrophile, to form a biaryl or substituted alkene structure. The exact result depends on the substrate, catalyst, base, solvent, temperature, and reaction work-up.

This reactivity makes the compound relevant to the preparation of substituted aromatic intermediates. Researchers may use it during medicinal chemistry library synthesis, lead optimization, route scouting, or preparation of reference compounds. I recommend treating published reaction conditions as starting points rather than guaranteed production conditions, because substrate sensitivity and scale can significantly affect conversion and impurity formation.

Pharmaceutical and Agrochemical Research

In pharmaceutical research, the para-methoxyphenyl group can be incorporated into candidate molecules to investigate changes in electronic properties, lipophilicity, binding behavior, or synthetic accessibility. In agrochemical research, the same building-block function can support the preparation of substituted aromatic intermediates. These statements describe chemical utility, not approval or suitability for a regulated product.

Specialty Synthesis and Route Development

Universities, contract research organizations, and specialty synthesis manufacturers may use this material for gram-scale experiments, parallel synthesis, or process feasibility studies. It can be particularly useful when a project requires a commercially available arylboronic acid rather than an internally prepared intermediate. For scale-up, I advise checking impurity profiles, water content, batch reproducibility, and reaction performance before committing to a larger purchase.

Specifications Buyers Should Review

A specification should begin with unambiguous identity: product name, CAS 5720-07-0, molecular formula, molecular weight, and a suitable analytical identification method. Buyers should request a current certificate of analysis for the offered lot rather than relying only on a catalog page. Depending on the application, the document may include assay, appearance, water content, residue on ignition, related substances, and analytical chromatograms.

For research-grade sourcing, a purity target of at least 98% is commonly requested, but the correct acceptance limit depends on the reaction and downstream requirements. I would not treat 98% as a universal guarantee unless it is stated in the supplier’s formal specification and confirmed on the lot-specific CoA. If the material is intended for a sensitive process, buyers may need a tighter related-substance profile or additional analytical information.

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How to Select the Right Supply Option

Step 1: Define the Intended Use

I first separate the requirement into reaction screening, routine laboratory use, process development, or commercial manufacturing. A small pack with standard documentation may be sufficient for exploratory chemistry, while a process program may require batch reservations, method alignment, and a defined impurity strategy. This first decision prevents buyers from comparing price alone.

Step 2: Match Quality to the Reaction

Next, I compare the required assay and impurity limits with the reaction’s sensitivity. Some coupling reactions tolerate minor impurities, while others may be affected by catalyst poisons, moisture, residual metals, or structurally related compounds. If the reaction is not yet established, I suggest purchasing a representative sample and testing it under the intended conditions before approving a larger lot.

Step 3: Confirm Packaging and Logistics

Packaging should protect the solid from contamination, excessive humidity, and avoidable handling exposure. Buyers should confirm net weight, container type, storage instructions, shipping documentation, and whether the supplier can maintain the same specification across repeat lots. For planning purposes, an indicative laboratory-order lead-time discussion may use a range such as 5–15 business days, but the actual schedule must be confirmed against stock, production status, destination, and order quantity.

Step 4: Evaluate Total Cost

The quoted price is only one part of sourcing cost. I also consider minimum order quantity, analytical documentation, sample availability, freight, import requirements, relabeling, and the cost of replacing a lot that fails internal testing. A slightly higher unit price may be commercially reasonable if it reduces qualification work or improves supply continuity, but that decision should be supported by project-specific data.

Pricing, MOQ, and Supplier Evaluation

Pricing for 4-Methoxyphenylboronic acid can vary with assay, pack size, production scale, market availability, documentation, and destination. A direct quotation is more reliable than a generic online price because the same product name may represent different grades and commercial terms. I recommend asking for prices at several quantities, such as laboratory, pilot, and production-relevant levels, while keeping the specification unchanged for a meaningful comparison.

MOQ should be discussed together with shelf-life information and demand forecasts. If annual consumption is uncertain, a smaller initial order or staged delivery can reduce inventory exposure. If demand is predictable, I can help customers discuss repeat-order planning, production scheduling, and packaging options through a formal inquiry.

Supplier Checklist

• Can the supplier clearly identify the product as CAS 5720-07-0?
• Is a current lot-specific CoA available for review?
• Are assay, impurity, moisture, and appearance requirements defined?
• Can the supplier provide the requested pack size and shipping format?
• Is there a clear process for sample approval, complaint handling, and repeat orders?
• Can the supplier discuss customization without making unsupported performance claims?

As Maison Chemical, I focus on supplying organic boronic acids for professional chemical buyers and project-based sourcing. I can discuss the required quantity, target specification, packaging, documentation, destination, and intended use before preparing a quotation. Product availability, lead time, and commercial terms should be confirmed for each inquiry rather than assumed from a general product description.

Common Purchasing Mistakes

One common mistake is ordering by name alone without confirming the CAS number and current specification. Another is treating a stated purity value as sufficient evidence without reviewing the analytical method or lot-specific CoA. Buyers may also overlook moisture sensitivity, storage conditions, import documentation, or the difference between a sample order and a repeatable commercial supply arrangement.

I also advise against scaling a literature reaction directly from milligrams to kilograms. Catalyst loading, mixing, heat transfer, phase behavior, work-up, and filtration can change substantially with scale. A small process check and a clear acceptance specification provide a more reliable basis for supplier qualification and production planning.

Key Takeaways and Next Steps

4-Methoxyphenylboronic acid CAS 5720-07-0 is an aryl boronic acid building block used mainly for Suzuki–Miyaura coupling and related organic synthesis applications. Its basic procurement profile includes formula C₇H₉BO₃, molecular weight approximately 151.96 g/mol, and a solid form that should be evaluated through current lot documentation. The most important buying factors are identity, assay, impurity control, moisture and packaging, documentation, MOQ, lead time, and repeat-lot consistency.

My recommended next step is to send Maison Chemical your target quantity, desired purity, packaging preference, destination, application category, and documentation requirements. I can then help determine whether a sample, standard research grade, or more tightly defined project specification is appropriate. Contact Maison Chemical for a product-specific quotation and supply discussion for 4-Methoxyphenylboronic acid CAS 5720-07-0.