What Is 3-Carboxyphenylboronic Acid CAS 25487-66-5? Properties, Uses, and Supplier Information

3-Carboxyphenylboronic acid, identified by CAS 25487-66-5, is an aromatic boronic acid that also contains a carboxylic acid group. I commonly describe it as a bifunctional building block for organic synthesis because the boronic acid group can participate in cross-coupling chemistry, while the carboxylic acid provides a second functional handle for downstream modification. Its molecular formula is C₇H₇BO₄, and its calculated molecular weight is approximately 165.94 g/mol.

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For pharmaceutical, agrochemical, materials, and specialty chemical development, this compound is generally evaluated as an intermediate rather than as a finished active ingredient. The correct grade depends on the intended reaction, impurity limits, scale, and documentation requirements. I recommend confirming the identity, assay, water content, residual solvents, packaging, and available analytical data before placing a commercial order.

Core Identity and Chemical Function

3-Carboxyphenylboronic acid contains a benzene ring substituted with both a carboxylic acid group and a boronic acid group in the meta, or 3-, position. This arrangement gives the molecule two chemically useful sites that can be manipulated in different stages of a synthetic route. The boronic acid group is especially relevant to carbon–carbon bond formation, while the carboxyl group may be used for esterification, amidation, salt formation, or other derivatization strategies.

The compound should not be confused with other positional isomers such as 2-carboxyphenylboronic acid or 4-carboxyphenylboronic acid. Although these isomers share the same molecular formula, their steric and electronic environments are different and can affect reaction behavior, purification, and final product performance. I therefore treat the CAS number and structural position as essential purchasing identifiers.

Key Properties to Consider

As an aromatic boronic acid, the material may be sensitive to moisture, pH, storage conditions, and prolonged exposure to conditions that promote boronic acid degradation or oxidation. Its apparent solubility can vary significantly with solvent, temperature, concentration, and ionization state. I do not recommend relying on a generic solubility statement when designing a process; instead, I suggest checking solvent compatibility at the actual concentration required by the route.

Core Functions in Chemical Synthesis

Suzuki–Miyaura Coupling Building Block

The principal synthetic value of 3-carboxyphenylboronic acid is its use as an aryl boronic acid coupling partner. In a Suzuki–Miyaura reaction, the aryl boronic acid can be combined with a suitable aryl or heteroaryl halide, commonly under palladium catalysis and in the presence of an appropriate base. This can create a biaryl bond while retaining or subsequently transforming the carboxylic acid group.

Reaction performance is route-dependent and should be confirmed through laboratory screening. Catalyst selection, base, solvent, temperature, concentration, substrate electronics, and purification method can all influence conversion and selectivity. For scale-up, I recommend monitoring boron-containing impurities and confirming that the isolation process is suitable for the desired quality level.

Dual-Functional Intermediate

The carboxylic acid group expands the use of this compound beyond simple aryl transfer. It may support the preparation of amides, esters, heterocycles, linker systems, and more complex pharmaceutical intermediates, subject to the chemistry selected by the development team. The two functional groups can also be used sequentially, allowing researchers to construct a molecular scaffold in stages.

Application Scenarios

In pharmaceutical research, 3-carboxyphenylboronic acid may be selected for medicinal chemistry libraries, lead optimization, and the preparation of advanced intermediates. Its value is associated with the ability to introduce a substituted aromatic ring and preserve a carboxylic acid for further coupling or polarity adjustment. Actual suitability must be confirmed for each target structure and reaction sequence.

In agrochemical and specialty chemical development, the compound may serve as an intermediate for functional aromatic molecules. It may also be considered in materials research where boron-containing aromatic structures are required. These applications are development-oriented, so buyers should distinguish between a research quantity, a process-development quantity, and a commercial manufacturing requirement.

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Types and Material Options

Suppliers may offer the product in different package sizes, assay ranges, and documentation formats. A small research package may be appropriate for route scouting, while a larger package may be required for process development or repeated pilot work. The most important distinction is not simply package size; it is whether the supplied specification matches the customer’s analytical and regulatory needs.

Some buyers may require a defined assay, a controlled impurity profile, lot-specific testing, or a particular packaging configuration. Others may need custom synthesis, technical consultation, or a repeat supply plan. I recommend identifying these requirements before quotation so that the supplier can evaluate feasibility accurately rather than providing a price based only on a catalog description.

How Buyers Should Evaluate Specifications

Identity and Assay

Start with confirmation of the CAS number, molecular formula, molecular weight, and structural name. Request a current certificate of analysis showing the tested assay and relevant analytical methods. Depending on the project, buyers may also ask for HPLC or GC data, NMR characterization, water content, residual solvents, and elemental or inorganic impurity information.

Handling and Packaging

Because boronic acids can be affected by environmental conditions, packaging should protect the material from unnecessary moisture and contamination. The exact storage recommendation should come from the product SDS and supplier specification rather than from a general assumption. I also recommend confirming the net weight, inner packaging, label format, transport classification, and shelf-life statement before shipment.

Supply Reliability

A competitive supplier should be evaluated on more than unit price. Buyers should review manufacturing location, batch consistency, analytical documentation, production capacity, response time, export experience, and the ability to support repeat orders. For time-sensitive projects, I suggest asking for a realistic lead time in business days and confirming whether the quoted material is in stock or requires production.

Supplier Support from Maison Chemical

At Maison Chemical, I position our support around practical B2B sourcing needs for 3-Carboxyphenylboronic acid CAS 25487-66-5. We can discuss the required grade, quantity, packaging, intended application, and documentation before preparing a quotation. This helps us distinguish a laboratory screening request from a process-development or recurring supply requirement.

Our team can also help buyers organize the information needed for technical evaluation, including product identification, available specification details, SDS documentation, packaging options, and shipment planning. Where a standard product specification does not fully match the project, the customer should describe the required assay, impurity limits, analytical method, and target quantity so feasibility can be assessed responsibly.

Purchasing Checklist

• Confirm that the product is 3-Carboxyphenylboronic acid with CAS 25487-66-5.
• Verify the molecular formula C₇H₇BO₄ and approximate molecular weight of 165.94 g/mol.
• Request a current certificate of analysis and SDS.
• Define the required assay, impurity profile, water content, and residual solvent limits.
• Confirm package size, packaging material, storage guidance, and shelf-life information.
• Ask whether the quoted quantity is available from stock or requires production.
• Review lead time, export documents, shipping terms, and repeat-order capability.

Conclusion: Is 3-Carboxyphenylboronic Acid the Right Intermediate?

3-Carboxyphenylboronic acid CAS 25487-66-5 is a useful bifunctional aromatic intermediate when a project requires both an aryl boronic acid coupling site and a carboxylic acid group. Its strongest fit is in synthetic routes involving Suzuki–Miyaura coupling, followed by or combined with carboxyl-group transformations. However, reaction compatibility, stability, purity, and handling requirements should be confirmed experimentally and through supplier documentation.

My recommended next step is to provide Maison Chemical with your target quantity, required assay, application, packaging preference, destination, and documentation requirements. We can then review the appropriate supply option and prepare a quotation based on the actual project conditions. This approach gives procurement and technical teams a clearer basis for selecting a dependable 3-Carboxyphenylboronic acid supply partner.

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