Sep. 15, 2026
Chemicals
Pyridine-3-boronic acid, also called 3-pyridylboronic acid or pyridin-3-ylboronic acid, is a heteroaryl boronic acid used mainly as a coupling building block in organic and medicinal chemistry. Its CAS number is 1692-25-7, molecular formula is commonly represented as C5H6BNO2, and its approximate molecular weight is 122.92 g/mol. I supply this intermediate through Maison Chemical for research, process development, and industrial sourcing, with product documentation and commercial terms confirmed according to the required grade, quantity, and destination.
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Pyridine-3-boronic acid is an organoboron compound in which a boronic acid functionality is attached to the 3-position of a pyridine ring. This structure combines the reactivity of an aryl or heteroaryl boronic acid with the nitrogen-containing characteristics of pyridine. In practical synthesis, the compound is valued because the boronic acid group can participate in carbon–carbon bond-forming reactions while the pyridine ring remains part of the final molecular framework.
The compound is generally handled as a solid chemical intermediate, although its physical appearance and assay may vary with manufacturing method, drying history, particle size, and storage conditions. Boronic acids can be sensitive to moisture and may exist in equilibrium with related boron-containing species under certain conditions. For that reason, I recommend evaluating the actual certificate of analysis and supplier storage guidance rather than relying only on a catalog description.
| Item | Information |
|---|---|
| Product name | Pyridine-3-boronic acid |
| CAS number | 1692-25-7 |
| Common synonyms | 3-Pyridylboronic acid; pyridin-3-ylboronic acid |
| Common molecular formula | C5H6BNO2 |
| Approximate molecular weight | 122.92 g/mol |
| Functional class | Heteroaryl boronic acid and pyridine building block |
The principal synthetic feature of Pyridine-3-boronic acid is its boronic acid group, which can be converted into a bond with a suitable aryl or vinyl halide under appropriate coupling conditions. The pyridine nitrogen adds a second point of chemical identity and can influence solubility, coordination, and the behavior of the resulting product. Reaction performance depends on the substrate, catalyst system, base, solvent, temperature, concentration, and work-up procedure.
In a typical Suzuki-type application, the boronic acid is combined with an electrophilic coupling partner such as an aryl halide or heteroaryl halide. The reaction is not automatically successful for every substrate, because catalyst poisoning, protodeboronation, steric effects, heteroatom coordination, and poor solubility can affect conversion. I therefore treat published reaction conditions as a starting point and recommend small-scale screening before process expansion.
For procurement, identity and purity are only part of the evaluation. Buyers often request assay, water content, residue on ignition or inorganic residue where relevant, appearance, and confirmation by analytical techniques such as NMR, chromatography, or mass spectrometry. The exact testing package should match the intended use, because a discovery-scale laboratory may need a different documentation level from a regulated or process-development program.
Pyridine-3-boronic acid is used as a building block for preparing substituted pyridines and more complex heteroaromatic molecules. Medicinal chemistry teams may use it to introduce a 3-pyridyl fragment into lead compounds during structure–activity relationship studies. Its value is practical: one commercially defined intermediate can help chemists explore multiple coupling partners without first preparing the pyridine fragment internally.
This compound should not be described as an active pharmaceutical ingredient or as a finished drug substance. It is a research and synthesis intermediate, and its suitability for a particular pharmaceutical route must be demonstrated through route-specific development, impurity assessment, and applicable quality controls. For regulated work, I recommend discussing residual solvents, elemental impurities, genotoxic impurity strategy, and change-control expectations at the quotation stage.
The 3-pyridyl structure occurs in many types of biologically active and functional molecules, making this boronic acid relevant to agrochemical discovery and specialty chemical development. It can serve as an intermediate for library synthesis, analog generation, and route scouting. The final application depends on the structure being produced, so the boronic acid itself should be evaluated as a synthesis input rather than assigned a performance claim for an end-use product.
Academic, contract research, and industrial laboratories may use Pyridine-3-boronic acid for reaction screening and method development. At this stage, small packs can be useful for comparing catalysts, bases, solvents, and coupling partners before committing to larger quantities. When a route advances, consistent lot quality and transparent documentation become more important than the initial catalog price alone.
First, I recommend defining whether the material is for exploratory chemistry, route development, scale-up, or a controlled manufacturing process. This decision influences the required purity, analytical package, packaging, and lot size. It also prevents over-specifying a product for a simple screening experiment or under-specifying one for a sensitive process route.
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Ask the supplier to confirm CAS 1692-25-7, nomenclature, formula, molecular weight, appearance, assay method, and any stated limits for water or related impurities. If the reaction is sensitive to moisture, request information about drying and packaging conditions. A reliable comparison requires equivalent specifications; two quotations cannot be judged fairly if one includes a detailed COA and the other provides only a nominal purity statement.
Price, MOQ, lead time, and shipping conditions should be assessed together. A lower unit price may not reduce total cost if the pack size is excessive, the delivery schedule is uncertain, or additional testing is required after receipt. For planning purposes, buyers should request a written quotation showing quantity, packaging, Incoterms, validity period, production or release timing, and document availability.
Lead time is dependent on stock status, batch release, quantity, packaging requirements, and destination. I do not recommend assuming a fixed delivery period without checking the current supply position. Maison Chemical can review the requested quantity and provide a practical supply proposal rather than applying one generic lead-time statement to every order.
One common mistake is selecting only by name while overlooking positional isomers. Pyridine-2-boronic acid, Pyridine-3-boronic acid, and Pyridine-4-boronic acid are different compounds, and the position of the boronic acid group changes the structure and synthetic outcome. Always compare the CAS number and structure, not just the shortened product name.
Another mistake is assuming that nominal purity predicts the exact result of every coupling reaction. Reaction behavior can also be influenced by moisture, particle form, impurities, substrate quality, and reaction design. I suggest testing a representative lot at small scale, documenting the observed performance, and then using the approved specification for repeat procurement.
Storage and handling should follow the supplier SDS and internal laboratory procedures. Keep the material in its original, properly closed container unless a validated transfer procedure is used, and protect it from conditions identified as unsuitable by the supplier. Because physical stability can depend on packaging and environment, buyers should avoid making unsupported assumptions about long-term storage without real-time or supplier-specific information.
At Maison Chemical, I focus on matching Pyridine-3-boronic acid CAS 1692-25-7 to the buyer’s actual technical and commercial requirements. We can discuss the desired quantity, purity target, packaging format, documentation, destination, and intended application before preparing a quotation. This approach helps create a clearer specification and reduces avoidable differences between laboratory evaluation and later procurement.
Our support may include sample coordination, product specification review, COA and SDS provision, packaging discussion, export documentation coordination, and repeat-order planning. The available quantity and delivery schedule should be confirmed for each inquiry, because they depend on current inventory, production arrangements, testing requirements, and shipping destination. Where a customer has a defined internal specification, I can review it with the supply team before commercial confirmation.
Pyridine-3-boronic acid CAS 1692-25-7 is a useful heteroaryl boronic acid for introducing a 3-pyridyl unit into synthetic molecules, particularly in Suzuki-type coupling and related research applications. Its core identifiers include the commonly used formula C5H6BNO2 and approximate molecular weight of 122.92 g/mol. The right purchasing decision depends on verified identity, fit-for-purpose purity, documentation, packaging, supply continuity, and route-specific performance.
For a quotation from Maison Chemical, send the required quantity, target specification, packaging preference, destination country, and desired delivery schedule. I can then help confirm product availability, documentation, MOQ, lead time, and shipment terms. For a new synthetic route, the most practical next step is to obtain a representative sample and lot-specific documents before moving to larger-scale procurement.
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